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			344 lines
		
	
	
		
			11 KiB
		
	
	
	
		
			Mathematica
		
	
	
	
	
	
			
		
		
	
	
			344 lines
		
	
	
		
			11 KiB
		
	
	
	
		
			Mathematica
		
	
	
	
	
	
| (* Mathematica Package *)
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| (* Created with IntelliJ IDEA and the Mathematica Language plugin *)
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| 
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| (* :Title: Importer for the RAW data-format of the Heidelberg Eye Explorer (known as HEYEX) *)
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| 
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| (* :Context: HeyexImport` *)
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| 
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| (* :Author: Patrick Scheibe pscheibe@trm.uni-leipzig.de *)
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| 
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| (* :Package Version: 1.0 *)
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| 
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| (* :Mathematica Version: 8.0 *)
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| 
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| (* :Copyright: Patrick Scheibe, 2013-2015 *)
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| 
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| (* :Discussion: This package registers a new importer which can load the RAW data-format exported by a
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|                 Heidelberg Spectralis OCT. The import-functionality can access different information contained
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|                 in a file:
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|                 1. The file header which contains meta data like when the patient was scanned etc
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|                 2. The scanned volume data
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|                 3. Images which represent slices of the scanned volume
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|                 4. The Scanning laser ophthalmoscopy (SLO) image which is taken with every scanned patient
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|                 5. The segmentation data for different retina layers provided by the software
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| 
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| *)
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| 
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| (* :Keywords: Import, Heyex, OCT, Spectralis, Heidelberg Engineering *)
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| 
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| BeginPackage[ "HeyexImport`" ]
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| 
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| HeyexEyePosition::usage = "HeyexEyePosition[file] tries to extract which eye was scanned, left or right.";
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| 
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| HeyexImport::wrongHdr = "Error importing OCT data. Broken/Wrong file?";
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| 
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| 
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| Begin[ "`Private`" ];
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| 
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| (*
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|     Registration of all import possibilities for the Heidelberg OCT.
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| *)
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| 
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| ImportExport`RegisterImport[
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|   "Heyex" ,
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|   {
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|     "FileHeader" :> importHeader,
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|     { "Data" , n_Integer} :> (importData[n][##]&),
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|     "Data" :> importData,
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|     { "Images" , n_Integer} :> (importImages[n][##]&),
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|     "Images" :> importImages,
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|     "SLOImage" :> importSLOImage,
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|     "SegmentationData" :> importSegmentation,
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|     { "SegmentationData" , n_Integer} :> (importSegmentation[n][##]&),
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|     "DataSize" :> importDataSize,
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|     importData
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|   },
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| 
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|   {
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|     "Image3D" :> (Image3D["Data" /. #1]&)
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|   },
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| 
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|   "AvailableElements" -> {"FileHeader", "Data", "DataSize", "Images", "SLOImage", "SegmentationData", "Image3D"}
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| ];
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| 
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| 
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| If[Quiet[Check[TrueQ[Compile[{}, 0, CompilationTarget -> "C"][] == 0], False]],
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|   $compileTarget = CompilationTarget -> "C",
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|   $compileTarget = CompilationTarget -> "MVM"
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| ];
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| 
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| 
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| (*
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|     Helper function which reads data from a stream. This is
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|     only a unification so I can map the read function over a
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|     list.
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| *)
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| read[{id_String, type_String}, str_] :=
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| id -> BinaryRead[str, type];
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| read[{type_String, n_Integer}, str_] := BinaryReadList[str, type, n];
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| read[{id_String, {type_String, n_Integer}}, str_] := id -> BinaryReadList[str, type, n];
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| (*
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|     Note that when reading bytes explicitly I convert them to
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|     a string and remove any zeroes at the end.
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| *)
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| read[{id_String, { "Byte" , n_Integer}}, str_] :=
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| id -> StringJoin[
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|     FromCharacterCode /@ (Rest[
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|       NestList[BinaryRead[str, "Byte" ] &, Null,
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|         n]] /. {chars___Integer, Longest[0 ...]} :> {chars})];
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| 
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| (*
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|     The layout of a file exported with "Raw Export"
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| 
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|     *****************
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|     *   File Header *
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|     *****************
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|     *   SLO Image   *
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|     *****************
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|     *   B-Scan #0   *
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|     *****************
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|     *   .....       *
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|     *****************
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|     *   B-Scan #n-1 *
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|     *****************
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| *)
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| 
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| With[{i = "Integer32", f = "Real32", d = "Real64", b = "Byte"},
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| 
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|   $fileHeaderInfo = Transpose[{
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|     {
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|       "Version" , "SizeX" , "NumBScans" , "SizeZ" , "ScaleX" , "Distance" ,
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|       "ScaleZ" , "SizeXSlo" , "SizeYSlo" , "ScaleXSlo" , "ScaleYSlo" ,
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|       "FieldSizeSlo" , "ScanFocus" , "ScanPosition" , "ExamTime" ,
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|       "ScanPattern" , "BScanHdrSize" , "ID" , "ReferenceID" , "PID" ,
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|       "PatientID" , "Padding" , "DOB" , "VID" , "VisitID" , "VisitDate" ,
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|       "Spare"
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|     },
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|     {
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|       {b, 12}, i, i, i, d, d, d, i, i, d, d, i, d, {b, 4}, {i, 2}, i, i,
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|       {b, 16}, {b, 16}, i, {b, 21}, {b, 3}, d, i, {b, 24}, d, {b, 1840}
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|     }
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|   }];
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| 
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|   $bScanHeaderInfo = Transpose[{
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|     {
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|       "Version" , "BScanHdrSize" , "StartX" , "StartY" , "EndX" , "EndY" ,
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|       "NumSeg" , "OffSeg" , "Quality" , "Spare"
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|     },
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|     {{b, 12}, i, d, d, d, d, i, i, f, {b, 196}}
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|   }];
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| ];
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| 
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| 
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| isHeyexRawFormat[{"Version" -> version_String, "SizeX" -> _Integer, "NumBScans" -> _Integer, _Rule..}] /; StringMatchQ[version, "HSF-OCT" ~~__] := True ;
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| isHeyexRawFormat[___] := False;
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| 
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| readFileHeader[str_InputStream] := With[{hdr = Quiet[read[#, str]] & /@ $fileHeaderInfo},
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|   hdr /; TrueQ[isHeyexRawFormat[hdr]]
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| ];
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| readFileHeader[___] := (Message[HeyexImport::wrongHdr]; Throw[$Failed]);
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| 
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| 
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| (*  Reads the camera image of the retina. Note that you must have the
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|     information from the fileheader and you must be at the right position
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|     of the file stream for this.*)
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| readSLOImage[str_InputStream, fileHdr : {(_String -> _) ..}] :=
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|   Image[Partition[
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|     BinaryReadList[str, "Byte" , "SizeXSlo" * "SizeYSlo" /. fileHdr],
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|     "SizeXSlo" /. fileHdr], "Byte" ];
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| 
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| skipSLOImage[str_InputStream, fileHdr : {(_String -> _) ..}] :=
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|   Skip[str, "Byte" , "SizeXSlo" * "SizeYSlo" /. fileHdr];
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| 
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| 
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| (*  One single BScan consists itself again of a header and a data part *)
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| readBScanHeader[str_InputStream, fileHdr : {(_String -> _) ..}] :=
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|   Module[{i = "Integer32", f = "Real32", d = "Real64", b = "Byte",
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|     bScanHdr},
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|     bScanHdr = read[#, str] & /@ Transpose[{
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|       { "Version" , "BScanHdrSize" , "StartX" , "StartY" , "EndX" , "EndY" ,
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|         "NumSeg" , "OffSeg" , "Quality" , "Spare" },
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|       {{b, 12}, i, d, d, d, d, i, i, f, {b, 196}}}
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|     ];
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|     AppendTo[bScanHdr,
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|       read[{ "SegArray" , { "Real32" ,
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|         "NumSeg" * "SizeX" /. bScanHdr /. fileHdr}}, str]
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|     ];
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|     (*
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|       This is horrible slow, therefore I just skip the fillbytes
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|    
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|       AppendTo[bScanHdr,
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|        read[{"Fillbytes", {"Byte",
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|           "BScanHdrSize" - 256 - "NumSeg"*"SizeX"*4 /. bScanHdr /.
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|            fileHdr}}, str]
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|        ]
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|    *)
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|     Skip[str, "Byte" , "BScanHdrSize" - 256 - "NumSeg" * "SizeX" * 4 /. bScanHdr /. fileHdr];
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|     AppendTo[bScanHdr, "FillBytes" -> None]
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|   ]
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| 
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| skipBScanHeader[str_InputStream, fileHdr : {(_String -> _) ..}] :=
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|   Skip[str, "Byte" , "BScanHdrSize" /. fileHdr];
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| 
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| readBScanData[str_InputStream, fileHdr : {(_String -> _) ..}] :=
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|   Module[{},
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|     Developer`ToPackedArray[
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|       Partition[read[{ "Real32" , "SizeX" * "SizeZ" /. fileHdr}, str],
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|         "SizeX" /. fileHdr]]
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|   ];
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| 
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| skipBScanData[str_InputStream, fileHdr : {(_String -> _) ..}] :=
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|   Skip[str, "Byte" , "SizeX" * "SizeZ" * 4 /. fileHdr];
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| 
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| skipBScanBlocks[str_InputStream, fileHdr : {(_String -> _) ..}, n_Integer] :=
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|   Skip[str, "Byte" , n * ("BScanHdrSize" + "SizeX" * "SizeZ" * 4) /. fileHdr];
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| 
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| 
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| importHeader[filename_String, ___] := Module[
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|   {str, header},
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|   str = OpenRead[filename, BinaryFormat -> True];
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|   header = readFileHeader[str];
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|   Close[str];
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|   "FileHeader" -> header
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| ];
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| 
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| 
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| (* Imports the dimension of the scanned volume. *)
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| importDataSize[filename_String, r___] := Module[{header = importHeader[filename]},
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|   "DataSize" -> ({"NumBScans", "SizeZ", "SizeXSlo"} /. ("FileHeader" /. header))
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| ]
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| 
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| importSLOImage[filename_String, ___] := Module[
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|   {str, header, slo},
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|   str = OpenRead[filename, BinaryFormat -> True];
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|   header = readFileHeader[str];
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|   slo = readSLOImage[str, header];
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|   Close[str];
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|   "SLOImage" -> slo
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| ]
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| 
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| importData[filename_String, ___] := Module[
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|   {str, header, nx, n, data},
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|   str = OpenRead[filename, BinaryFormat -> True];
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|   header = readFileHeader[str];
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|   {nx, n} = { "SizeX" , "SizeX" * "SizeZ"} /. header;
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|   skipSLOImage[str, header];
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|   data = Table[
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|     skipBScanHeader[str, header];
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|     Partition[read[{ "Real32" , n}, str], nx],
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|     {"NumBScans" /. header}
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|   ];
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|   Close[str];
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|   "Data" -> Developer`ToPackedArray[data]
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| ];
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| 
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| importData[num_Integer][filename_String, ___] := Module[
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|   {str, header, nx, n, data},
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|   str = OpenRead[filename, BinaryFormat -> True];
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|   header = readFileHeader[str];
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|   {nx, n} = { "SizeX" , "SizeX" * "SizeZ"} /. header;
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|   skipSLOImage[str, header];
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|   skipBScanBlocks[str, header, Max[Min["NumBScans" /. header, num - 1], 0] ];
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|   skipBScanHeader[str, header];
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|   data = Partition[read[{ "Real32" , n}, str], nx];
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|   Close[str];
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|   {"Data" -> {num -> Developer`ToPackedArray[data]}}
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| ];
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| 
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| (*
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|     As suggested in the Heidelberg OCT Manual the importer will adjust
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|     the graylevels when importing images. Since this is very time-consuming
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|     for the whole scanned volume, I use an optimized version of this function.
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| *)
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| With[{$compileTarget = $compileTarget}, $adjustGraylevelFunc := ($adjustGraylevelFunc = Compile[{{values, _Real, 2}},
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|   Map[Floor[255.0 * Min[Max[0.0, #], 1.0]^(0.25) + 0.5] &, values, {2}],
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|   RuntimeAttributes -> {Listable},
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|   Parallelization -> True,
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|   RuntimeOptions -> "Speed",
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|   $compileTarget
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| ])];
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| 
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| importImages[filename_String, ___] := Module[
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|   {data},
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|   data = "Data" /. importData[filename];
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|   "Images" -> (Image[#, "Byte" ]& /@ $adjustGraylevelFunc[data])
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| ]
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| 
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| importImages[imageNumber_Integer][filename_String, ___] := Module[
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|   {data},
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|   data = {imageNumber /. ("Data" /. importData[imageNumber][filename])};
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|   {"Images" -> {imageNumber -> (Image[#, "Byte" ]& @@ $adjustGraylevelFunc[data])}}
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| ];
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| 
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| importSegmentation[filename_String, ___] := Module[
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|   {str, header, data},
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|   str = OpenRead[filename, BinaryFormat -> True];
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|   header = readFileHeader[str];
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|   skipSLOImage[str, header];
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|   data = Table[
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|     Module[{bScanHeader, t},
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|       {t, bScanHeader} = Timing@readBScanHeader[str, header];
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|       skipBScanData[str, header];
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|       bScanHeader
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|     ], {"NumBScans" /. header}
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|   ];
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|   Close[str];
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|   (*
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|       The BScanHeaderData contain the segmentation vectors as a single list
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|       of numbers. Before returning the result, I check how many segmentations
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|       there are inside the BScan an I transform the segmentation value list
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|       into separate vectors and call them "ILM", "RPE" and "NFL" like described
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|       in the manual
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|       *)
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|   "SegmentationData" -> Function[{bhdr},
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|     Block[{numVecs = "NumSeg" /. bhdr, vecNames, nx = "SizeX" /. header},
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|       If[numVecs > 0,
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|         vecNames = Take[{ "ILM" , "RPE" , "NFL" }, numVecs];
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|         bhdr /. ("SegArray" -> vec_) :> Sequence @@ (Rule @@@ Transpose[{vecNames, Partition[vec, nx]} ]),
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|         bhdr
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|       ]
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|     ]] /@ data
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| ]
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| 
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| importSegmentation[num_Integer][filename_String, ___] := Module[
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|   {str, header, bhdr},
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|   str = OpenRead[filename, BinaryFormat -> True];
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|   header = readFileHeader[str];
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|   skipSLOImage[str, header];
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|   skipBScanBlocks[str, header, Max[Min["NumBScans" /. header, num - 1], 0] ];
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|   bhdr = readBScanHeader[str, header];
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|   Close[str];
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|   (* See doc above *)
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|   {"SegmentationData" -> {num -> Block[
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|     {numVecs = "NumSeg" /. bhdr, vecNames, nx = "SizeX" /. header},
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|     If[ numVecs > 0,
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|       vecNames = Take[{ "ILM" , "RPE" , "NFL" }, numVecs];
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|       bhdr /. ("SegArray" -> vec_) :> Sequence @@ (Rule @@@ Transpose[{vecNames, Partition[vec, nx]} ]),
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|       bhdr
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|     ]
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|   ]
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|   }}
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| ]
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| 
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| (* Extracts which eye was scanned. This is stored in the header of the file *)
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| (* OD stands for oculus dexter which is latin for "right eye" and OS stands
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|    for oculus sinister which is latin for "left eye" *)
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| HeyexEyePosition[file_String /; FileExistsQ[file]] := Module[{position},
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|   Check[
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|     position = "ScanPosition" /. Import[file, { "Heyex" , "FileHeader" }];
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|     Switch[
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|       position,
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|       "OD" ,
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|       Right,
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|       "OS" ,
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|       Left,
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|       _,
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|       $Failed
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|     ],
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|     $Failed
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|   ]
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| ];
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| 
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| End[]
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| 
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| EndPackage[] |